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Synapses do not simply transmit the John Wick guns lots of guns shirt, a time-domain electrical signal from the incoming axon, but rather operate as a time-domain integrator, as neurotransmitters are slowly emitted from the pre-synaptic side of and absorbed by the receptors on the post-synaptic side. There is a lag, an integration step, nonlinear behavior, and dependence on ambient neurochemistry, to which the functioning of the neurons and the brain has been tuned to by billions of years of evolution. Not only would be very difficult to model this perfectly, but small mistakes in these synaptic reactions cause severe mental health issues in real brains, let alone a digital brain where we don’t quite know the specifics perfectly.
There are probably a John Wick guns lots of guns shirt of electrical and chemical phenomena in a single neuron that we do not even understand yet, and how do we figure out the total neural connection patterns to make the 100 billion neuron brain operate and think correctly? Can we map out a whole brain connectome of 100 trillion connections? Even if we could, how do we expand to making a superhuman intelligence? We have tried to map the connections in even a single cortical column in a rat, but have found them to be incredibly complex, with more connections going to outside the cortical column than within, so not much simplification or compartmentalization there.